中药资源科学与工程研究中心
王魁
发布时间:2021-02-22      来源:       点击:

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王魁,博士,研究员,博士生导师,广东省珠江人才计划-青年拔尖人才,威尼斯欢乐娱人城v3676杏林青年学者,主持国家自然科学基金等各级项目7项,以第一/通讯作者在Biotechnol Biofuels、Int J Biol Macromol、Appl Microbiol Biot、J Agr Food Chem等国际专业期刊发表SCI论文12篇,获国家发明专利2项。受邀担任粤港澳科技合作专题项目、广东省创新基金项目、广东省自然科学基金面上项目 、广东省基础与应用基础基金区域联合基金项目 (通讯) 评审专家,并受邀担任 Journal of Agricultural and Food Chemistry、Applied Microbiology and Biotechnology、Process Biochemistry、Frontiers in Microbiology等专业期刊的审稿人。

E-mail: kuiwang@gzucm.edu.cn;uk0829@126.com

课题组主页:https://www.x-mol.com/groups/wangkui/people/6364

学习工作经历

2016/10−至今,威尼斯欢乐娱人城v3676 (岭南中药资源教育部重点实验室),研究员

2014/03−2016/08,美国伊利诺伊大学香槟分校 (公立常春藤名校),博士后

2012/07−2014/03,东莞泛亚太生物科技有限公司,工业酶研发,研发经理

2007/10−2012/06,中山大学,微生物学与酶工程学,获理学博士学位

2003/09−2007/07,南昌大学,生物工程,获工学学士学位

研究领域及方向

(1) 工业微生物菌种选育。

(2) 工业用非淀粉多糖水解酶的开发。

(3) 中药废弃物和农林废弃物的资源化利用。

(4) 功能性低聚糖的酶法制备。

(5) 中药活性成分的微生物合成等领域的研究。

主持的科研项目

(1) 广东省“珠江人才计划—青年拔尖人才”项目 (2017GC010372),2018.01−2022.12

(2) 国家自然科学基金青年科学基金项目 (31802099),2019.01−2021.12

(3) 广东省自然科学基金 (2018A030310497),2018.05−2021.04

(4) 广东省基础与应用基础研究基金青年基金项目 (2019A1515110914),2020.01−2022.12

(5) 广东省普通高校青年创新人才项目 (2017KQNCX037),2018.01−2019.12

(6) 威尼斯欢乐娱人城v3676高水平大学建设项目 (广中医研 [2017]10 号),2017.03−2018.09

(7) 威尼斯欢乐娱人城v3676“杏林青年学者”启动经费,2017.01−2021.12

(8) 中国波顿集团产业研究院岗位专家,2021.01−2022.12

代表性研究论文 (#, 共同第一作者;*,通讯作者)

1.Xi Chen#, Xinhai Wang#, Yun Liu, Ruoting Cao, Sidi Wang, Ruoting Zhan, Kui Wang*. Biochemical analyses of a thermostable GH5 endo β-1,4-mannanase exhibiting β-1,4 glucosidic cleavage activity from Bacillus sp. KW1 and its synergism with a commercial α-galactosidase in galactomannan hydrolysis. International Journal of Biological Macromolecules, 2021, 166: 778−788.

2.Qibin Lin#, Sidi Wang#, Meiling Wang, Ruoting Cao, Ruiqing Zhang, Ruoting Zhan, Kui Wang*. A novel glycoside hydrolase family 42 enzyme with bifunctional beta-galactosidase and alpha-L-arabinopyranosidase activities and its synergistic effects with cognate glycoside hydrolases in plant polysaccharides degradation. International Journal of Biological Macromolecules, 2019, 140: 129−139.

3.Kui Wang#,*, Ruoting Cao#, Meiling Wang, Qibin Lin, Ruoting Zhan, Hui Xu, Sidi Wang*. A novel thermostable GH10 xylanase with activities on a wide variety of cellulosic substrates from a xylanolytic Bacillus strain exhibiting significant synergy with commercial Celluclast 1.5 L in pretreated corn stover hydrolysis. Biotechnology for Biofuels, 2019, 12: 48.

4.Zhixue Wu#, Hui Xu#, Meiling Wang, Ruoting Zhan, Weiwen Chen, Kui Wang*, Jiangyong Gu*. Molecular docking and molecular dynamics studies on selective synthesis of alpha-amyrin and beta-amyrin by oxidosqualene cyclases from Ilex asprella. International Journal of Molecular Sciences, 2019, 20: 3469.

5.Kui Wang, Gabriel Vasconcelose Pereira, Janaina Cavalcante, Meiling Zhang, Roderick Mackie, Isaac Cann*. Bacteroides intestinalis DSM 17393, a member of the human colonic microbiome, upregulates multiple endoxylanases during growth on xylan. Scientific Reports, 2016, 6: 34360.

6.Kui Wang, Yi Lu, Weiqu Liang, Sidi Wang, Yang Jiang, Rui Huang, Yuhuan Liu*. Enzymatic synthesis of Galacto-oligosaccharides in an organic-aqueous biphasic System by a novel β-galactosidase from a metagenomic library. Journal of Agricultural and Food Chemistry, 2012, 60: 3940−3946.

7.Kui Wang#, Gang Li#, Shi Qin Yu, Chen Ting Zhang, Yuhuan Liu*. A novel metagenome-derived beta-galactosidase: gene cloning, overexpression, purification and characterization. Applied Microbiology and Biotechnology, 2010, 88: 155−165.

8.Gang Li#, Kui Wang#, Yuhuan Liu*. Molecular cloning and characterization of a novel pyrethroid-hydrolyzing esterase originating from the metagenome. Microbial Cell Factories, 2008, 7: 38.

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