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刘四军
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刘四军

职称/职位:医学博士,中药学教授,博生研究生导师,美国哈佛医学院访问学者,威尼斯欢乐娱人城v3676第一附属医院主任中医师,广东省中医师承导师,中华中医药学会中药基础理论分会委员,《中华人民共和国药典(临床用药须知)》编写专家,Neuroscience Letters审稿人,Stem Cells International审稿人,Journal of Dental Problems and solution审稿人。目前担任了高等学校中医学类专业核心课程中药学课程联盟秘书,中华中医药学会中药基础理论分会委员,广东省药理学会内分泌代谢病药理学会常务委员,国家级一流本科课程《中药学》主要参与人,国家中医药管理局重点学科《临床中药学》主要参与人,SCI收录期刊Neuroscience Letters审稿人,Stem Cells International审稿人,Journal of Dental Problems and solution审稿人。主讲《中药学》、《临床中药学》等理论和实验课程,《新药研究与开发应用》课程负责人。

教育工作经历

2022/01至今    威尼斯欢乐娱人城v3676  威尼斯欢乐娱人城v3676     教授

2017/1-2022/01    威尼斯欢乐娱人城v3676  威尼斯欢乐娱人城v3676     副教授

2019/10-2020/11 美国Harvard Medical School    访问学者

2008/7-2016/12 威尼斯欢乐娱人城v3676 威尼斯欢乐娱人城v3676 助教、讲师

2010/07-2013/06 威尼斯欢乐娱人城v3676 临床药理研究所 博士

2005/09-2008/07 威尼斯欢乐娱人城v3676 威尼斯欢乐娱人城v3676 硕士

2000/09-2005/07 湖南中医药大学 中医学 学士

研究方向

1)中药药性理论

2)老年性痴呆的临床与实验研究

科研及教学课题

1.国家自然基金面上项目,82374054,基于“淡味渗泄”探讨当归芍药散调控脑-肠轴防治AD的药性基础,2024.01-2027.12,48万元,在研,主持

2.国家自然基金面上项目,81973497,当归芍药散基于双向调控RascAMP-dependent PKA自噬通路的“酸甘化阴、辛甘化阳”的药性基础,2020.01-2023.12,55万元,在研,主持

3.国家自然科学基金面上项目,81673619,基于“辛润”药性理论的当归芍药散对hiPSC技术建立肝肾亏虚AD模型的作用机制研究,2017/01-2020/12,72万元,在研

4.国家自然科学基金面上项目,81273817,当归芍药散改善痴呆动物脑微血管内皮细胞功能障碍及调节血脑屏障Aβ转运机制的研究,2013/01-2016/12,72万元,结题

5.广东省自然科学基金项目,2015A030310414,石菖蒲有效成分对APP/PS双转基因小鼠的学习记忆及神经元突触可塑性的影响,2015/08-2018/08,10万元,已结题,主持

6.广东省重大科技专项,2012A080202017,补肾益智方有效部位治疗老年性痴呆的新药研究,2013/01-2015/12,120万元。已结题

7.广东省中医药局项目,20121225,β-细辛醚、丁香酚及配伍防治AD的作用及机制研究,2012/06-2014/06,0.5万元,结题,主持。

8.教育部高等学校博士学科点专项科研基金,20114425110007,石菖蒲组分配伍对转基因痴呆小鼠学习记忆和神经元突触可塑性影响的研究,2012/01-2014/12,12万元,结题。

承担课程

承担全校本专科、成教、西学中等各层次的《中药学》、《临床中药学》课程教学;《新药研究与开发应用》课程负责人。

代表性论著

(1)刘四军(编委).中药学(“十四五”普通高等教育本科规划教材)[M].北京:科学出版社,2022

(2)刘四军(编委).中药学(全国中医药行业高等教育“十四五”规划教材)[M].北京:中国中医药出版社,2023

(3)刘四军(参编).2010版中华人民共和国药典(临床用药须知)[M].北京:中国医药科技出版社,2011.04

(4)刘四军(副主编).中华养生药茶[M].合肥:安徽科学技术出版社.2012.02

(5)刘四军(编委).岭南本草[M].广州:广东科技出版社,2010

(6)刘四军(副主编).中药处方点评[M].北京:人民卫生出版社,2017

(7)刘四军(副主编).五官科中成药实用手册[M].北京:人民卫生出版社,2018

(8)刘四军(编委).新编中国药材学[M].北京:中国医药科技出版社,2020

代表性研究论文

(1)Zhou X, Chen X, Cheng X, Lin L, Quan S, Li S, Zhan R, Wu Q, Liu S*. Paeoniflorin, ferulic acid, and atractylenolide III improved LPS-induced neuroinflammation of BV2 microglia cells by enhancing autophagy. J Pharmacol Sci. 2023 Jun;152(2):151-161.

(2)Chen X, Zhou X, Cheng X, Lin L, Wang Q, Zhan R, Wu Q, Liu S*. Protective Effect of Ferulic Acid on Lipopolysaccharide-Induced BV2 Microglia Inflammation via AMPK/mTOR Signaling Pathway. Molecules. 2023 Apr 14;28(8):3482.

(3)Liu S, Wang Z, Long X, Fleishman A, Huang X, Wu Q, Gershman B, Olumi AF. Single black men have the worst prognosis with localized prostate cancer. Can J Urol. 2022 Feb;29(1):10992-11002. PMID: 35150221.            

(4) Sijun Liu, Yuying Zhao, Xiaoying Su, Chengcheng Zhou, Peifen Yang, Qiusan Lin, Shijun Li, HanxuTan, Qi Wang, Changjun Wang, and Qingguang Wu. Re-construction of Alzheimer’s Disease Cell Model in Vitro via Extracted Peripheral Blood Molecular Cells from a Sporadic Patient. Stem Cells International. 2020 Dec 7;https://doi.org/10.1155/2020/8897494( IF 3.869)

(5)Zhao W, Deng J, Ren Y, Xie L, Li W, Wang Q, Li S, Liu S*. Antibacterial application and toxicity of metal-organic frameworks. Nanotoxicology. 2020 Dec 1:1-20. doi: 10.1080/17435390.2020.1851420. Epub ahead of print. PMID: 33259255.  ( IF 4.925)

(6)Lianzhu Lin, Kun Yang , Lin Zhengc , Mouming Zhao, Weizheng Sun, Qiyuan Zhu , Sijun Liu. Anti-aging effect of sea cucumber (Cucumaria frondosa) hydrolysate on fruit flflies and D-galactose-induced aging mice.Journal of Functional Foods, 2018,47:11–18.

(7)Wentao Wei, Zhenyu Chen,Yonglu Lin, Rixing Chen,Qi Wang,  Qingguang Wu, Sijun Liu,* Ming Yan, , and Xuejing Zhang*. Synthesis of Isoindolinones through Intramolecular Amidation of ortho-Vinyl Benzamides.Advanced Synthesis and Catalysis ( IF 5.451 ) Pub Date : 2020-04-08 , DOI: 10.1002/adsc.202000260

(8)Lianzhu Lin, Kun Yang , Lin Zhengc , Mouming Zhao, Weizheng Sun, Qiyuan Zhu , Sijun Liu. Preparation of sea cucumber (Stichopus variegates) peptide fraction with desired organoleptic property and its anti-aging activity in fruit flies and D-galactose-induced aging mice. Journal of Functional Foods, 2020,69:1–12. https://doi.org/10.1016/j.jff.2020.103954

(9)Zhou C, Wu Q, Wang Z, Wang Q, Liang Y, Liu S*. The Effect of Hormone Replacement Therapy on Cognitive Function in Female Patients With Alzheimer's Disease: A Meta-Analysis. Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317520938585. doi: 10.1177/1533317520938585. PMID: 32677442.

(10)Liu S, Yang C, Zhang Y, Su RY, Chen JL, Jiao MM, Chen HF, Zheng N, Luo S, Chen YB, Quan SJ, Wang Q. Neuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1. Drug Design, Development and Therapy. 2016, 10:1461-1469. PMID: 27143853

(11)Liu S, Huang Z, Wu Q, Huang Z, Wu L, Yan W, David L, Yang Z , Wang  Z .Quantization and diagnosis of Shanghuo (Heatiness) in Chinese medicine using a diagnostic scoring scheme and salivary biochemical parameters. Chinese Medicine. 2014, 9(2):1-10. PMID: 24386887

(12)Liu S, Huang Z, Wu Q, Huang Z, Wu L, Yan W, Wang Q, Wang Z, David, Yang Z. Study on diagnosis criteria of fire-heat syndrome based on ROC curve and principal component analysis. Chinese Journal of Integrative Medicine. 2014, 22(4):258-266. PMID: 25519441

(13)Gao J, Wang Q, Xian S, Feng Y, Cao W, Ye J, Zhang Q, Zou C, Wu Q, Liu S*. The effect of moxibustion on alleviating menstrual pain in a population of young nursing students: A prospective randomized cross-overpilot study. Complementary Therapies in Medicine. 2015, 23(6):773–781. PMID: 26645515

专利

(1)PCT专利1:Heatiness and salivary secretory immunoglobulin (NO.2011384377B2),Accepted Date:2014.9.18

(2)PCT专利2:Methods and products to diagnose and treat heatiness (NO.2011384378B2),Accepted Date:2014.9.18

(3)发明专利:一种铜@大黄蒽醌金属有机框架复合物及其应用.专利号:CN202010357062.3,2022

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