2021/2-至今     威尼斯欢乐娱人城v3676  威尼斯欢乐娱人城v3676（国际中医药转化医学研究所）研究员

2020/9-2020/12  美国堪萨斯大学医学中心 药理毒理与治疗系 研究助理教授

2016/7-2020/8   美国堪萨斯大学医学中心 药理毒理与治疗系 博士后

2013/11-2016/6  美国堪萨斯大学医学中心 药理毒理与治疗系 国际联合培养博士

2010/9-2016/6   中山大学 药学院 博士

2006/9-2010/6   中山大学 药学院 学士

（1）细胞器互作在消化代谢疾病中的作用与机制研究；

（2）自噬调控在消化代谢疾病中的作用与机制研究；

（3）细胞死亡类型在消化代谢疾病发病进程中的机制研究

（1）酒精及药物诱导胰腺炎的发病机制及治疗靶点研究；

（2）酒精及药物诱发肝损伤的发病机理研究；

（3）肝脏肿瘤发病进程及机制研究

1.国家自然科学基金委员会，面上项目，82370660，TFEB调控线粒体分布在急性胰腺炎中的作用机制及干预策略，2024/01-2027/12，在研，主持；

2.国家自然科学基金委员会，青年科学基金项目，82000612，PGC-1α调控线粒体生物合成在急性胰腺炎中的研究，2021/01-2023/12，在研，主持；

3.威尼斯欢乐娱人城v3676，“高水平大学建设人才项目”，2021/02-2026/02，在研，主持；

4.威尼斯欢乐娱人城v3676，青年拔尖人才培育“揭榜挂帅”个人项目，2023/10-2026/10，在研，主持；

5. 威尼斯欢乐娱人城v3676，青年拔尖人才培育“揭榜挂帅”团队项目，2023/10-2026/10，在研，主要参与人；

6. 美国博士后研究项目，Critical Role of VMP1-Mediated ER Homeostasis in the Pathogenesis of Pancreatitis，2020/01-2020/12，$13,000，结题，主持；

7.美国国立卫生研究院-酒精滥用与酒精中毒研究所（NIAAA），U01 AA024733，Autophagy in Alcoholic Pancreatitis. 2017/05-2022/04，$1,721,250，结题，参加，主要完成人；

8.美国国立卫生研究院-酒精滥用与酒精中毒研究所（NIAAA），R01 AA020518，Mechanisms regulating autophagy in alcohol-induced liver injury. 2011/05-2022/07，$3,363,875，结题，参加，主要完成人；

9.美国国立卫生研究院-国立医学科学研究所（NIGMS），P30 GM118247，Mechanisms of Liver Injury and Diseases. 2016/08-2021/07，$5,432,283，结题，参加，主要完成人；

（1）科学研究：以第一作者（含共同一作）及共同作者在Gastroenterology, Journal of Hepatology, Hepatology, Autophagy, Cell Reports, Acta Pharmacologica Sinica, Cellular and Molecular Gastroenterology and Hepatology等国际主流杂志发表论文50篇，谷歌学术引用2178次，H-index=27；

（2）学术兼职：eGastroenterology青年编委，Frontiers in Pharmacology副编委。Acta Pharmaceutica Sinica B, Biomed Research International, Biomedicine & Pharmacotherapy, Cellular Signalling, Evidence-Based Complementary and Alternative Medicine, Experimental Biology and Medicine, Journal of Functional Foods, Journal of Diabetes and Its Complications, Journal of Diabetes Research, Scientific Reports等10个国际SCI期刊审稿人；

（3）学术交流：受邀参加2022&2023年广东省药理学会，2021年扬州胰腺论坛，2020年Experimental Biology (EB)，2017&2019年Gordon Research Conference (GRC): Alcohol-Induced End Organ Disease，2015&2018年Central States Society of Toxicology Annual Meeting (CSSOT)等国际及国内大会并做大会口头和海报汇报，获EB、GRC和CSSOT等大会优秀青年学者参会津贴奖4次和最佳海报奖3次。

1. Tian-tian Wang, Li-chun Zhang, Zhen Qin, Shu-jun Chen, Jing-min Zeng, Jing-yan Li, Lin An, Cai-yan Wang, Yong Gao, Li-ming Wang, Zhong-xiang Zhao*, Zhong-qiu Liu*, Shao-gui Wang*. Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation. Acta Pharmacol Sin. 2023 Aug 14. doi: 10.1038/s41401-023-01139-x.

2.Zeyuan Lin, Shanshan Li, Haiming Xiao, Zhanchi Xu, Chuting Li, Jingran Zeng, Shaogui Wang*, Zhongqiu Liu*, Heqing Huang*. The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy. Cell Reports. 2023 Aug 29;42(8):112851.

3. Zi-bo Li, Lin Jiang, Jia-dong Ni, Yuan-hang Xu, Fang Liu, Wen-ming Liu, Shao-gui Wang*, Zhong-qiu Liu*, Cai-yan Wang*. Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells. Acta Pharmacol Sin, 2023 Jun;44(6):1191-1205.

4. Xiaojuan Chao, Shaogui Wang, Xiaowen Ma, Chen Zhang, Hui Qian, Sha Neisha Williams, Zhaoli Sun, Zheyun Peng, Wanqing Liu, Feng Li, Namratha Sheshadri, Wei-Xing Zong, Hong-Min Ni, Wen-Xing Ding*. Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis. Hepatology. 2023 Aug 1;78(2):503-517.

5. Hui Qian, Xiaojuan Chao, Shaogui Wang, Yuan Li, Xiaoxiao Jiang, Zhaoli Sun, Thomas Rülicke, Kurt Zatloukal, Hong-Min Ni, Wen-Xing Ding. Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-induced Liver Injury in Aged Mice. Cell Mol Gastroenterol Hepatol. 2023;15(5):1027-1049.

6.Wang, Shaogui; Chao, Xiaojuan; Jiang, Xiaoxiao; Wang, Tiantian; Rodriguez, Yssa; Yang, Ling; Pacher, Pal; Ni, Hong-Min; Ding, Wen-Xing*; Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice. Autophagy. 2022 Jul;18(7):1572-1582.

7. Chao, Xiaojuan#, Wang, Shaogui#, Fulte, Sam, Ma, Xiaowen, Ahamed, Forkan, Cui, Wei, Liu, Zhipeng, Rülicke, Thomas, Zatloukal, Kurt, Zong, Wei-Xing, Liu, Wanqing, Ni, Hong-Min*, Ding, Wen-Xing*; Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy. Journal of Hepatology, 2022 Mar;76(3):639-651.

8.Wang, Shaogui; Ni, Hong-Min; Chao, Xiaojuan; Ma, Xiaowen; Kolodecik, Thomas; De Lisle, Robert; Ballabio, Andrew; Pacher, Pal; Ding, Wen-Xing*; Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans. Cellular and Molecular Gastroenterology and Hepatology, 2020, 10(1): 59-81. 杂志封面文章

9.Wang, Shaogui; Ni, Hong Min; Chao, Xiaojuan; Wang, Hua; Bridges, Brian; Kumer, Sean; Schmitt, Timothy; Mareninova, Olga; Gukovskaya, Anna; De Lisle, Robert C; Ballabio, Andrea; Pacher, Pal; Ding, Wen-Xing*; Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis. Autophagy, 2019, 15(11):1954-1969.

10.Ni, Hong-Min*; Chao, Xiaojuan; Yang, Hua; Deng, Fengyan; Wang, Shaogui; Bai, Qingyun; Qian, Hui; Cui, Yue; Cui, Wei; Shi, Yinghong; Zong, Wei-Xing; Wang, Zhengtao; Yang, Li; Ding, Wen-Xing*; Dual Roles of Mammalian Target of Rapamycin in Regulating Liver Injury and Tumorigenesis in Autophagy-Defective Mouse Liver. Hepatology, 2019, 70(6): 2142-2155.

11.Wang, Hua; Ni, Hong Min; Chao, Xiaojuan; Ma, Xiaowen; Rodriguez, Yssa Ann; Chavan, Hemantkumar; Wang, Shaogui; Krishnamurthy, Partha; Dobrowsky, Rick; Xu, De Xiang; Jaeschke, Hartmut; Ding, Wen Xing*; Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice. Redox Biology, 2019, 22: 0-UNSP101148.

12.Wang, Shaogui; Ding, Wen Xing*; Does Autophagy Promote or Protect Against the Pathogenesis of Pancreatitis? Gastroenterology, 2018, 155(4):1273-1274.

13.Wang, Shaogui; Wang, Hua; Ding, Wen Xing*; Pyroptosis, A novel player for alcoholic hepatitis? Hepatology, 2018, 67(5): 1660-1662.

14.Chao, Xiaojuan#; Wang, Shaogui#; Zhao, Katrina; Li, Yuan; Williams, Jessica A; Li, Tiangang; Chavan, Hemantkumar; Krishnamurthy, Partha; He, Xi C; Li, Linheng; Ballabio, Andrea; Ni, Hong Min*; Ding, Wen Xing*; Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice. Gastroenterology, 2018, 155(3):865-879.

15.Wang, Shaogui; Ding, Wen Xing*; A small RNA in neutrophils protects against acute-on-chronic alcoholic liver injury. Gut, 2017, 66(4): 565-566.